The G-CSF-induced changes of IL-6, BDNF and IGF-1, and BDNF levels before treatment, could be used as prognostic factors in G-CSF trials in CP children.
Both BMD and IGF-1 were significantly in low children with spastic CP; IGF-1 negatively correlates with the severity of osteopenia in children with spastic.
In 25 CP children with osteopenia (Z-score >-1), there was a trend towards correlation between spinal BMD Z-score and serum IGF-1 SDS score (r = 0.328, p = 0.09).